病变分割是放射线工作流程的关键步骤。手动分割需要长时间的执行时间，并且容易发生可变性，从而损害了放射线研究及其鲁棒性的实现。在这项研究中，对非小细胞肺癌患者的计算机断层扫描图像进行了深入学习的自动分割方法。还评估了手动与自动分割在生存放射模型的性能中的使用。方法总共包括899名NSCLC患者（2个专有：A和B，1个公共数据集：C）。肺部病变的自动分割是通过训练先前开发的建筑NNU-NET进行的，包括2D，3D和级联方法。用骰子系数评估自动分割的质量，以手动轮廓为参考。通过从数据集A的手动和自动轮廓中提取放射性的手工制作和深度学习特征来探索自动分割对患者生存的放射素模型对患者生存的性能的影响。评估并比较模型的精度。结果通过平均2D和3D模型的预测以及应用后处理技术来提取最大连接的组件，可以实现具有骰子= 0.78 +（0.12）的自动和手动轮廓之间的最佳一致性。当使用手动或自动轮廓，手工制作或深度特征时，在生存模型的表现中未观察到统计差异。最好的分类器显示出0.65至0.78之间的精度。结论NNU-NET在自动分割肺部病变中的有希望的作用已得到证实，从而大大降低了时必的医生的工作量，而不会损害基于放射线学的生存预测模型的准确性。

Artificial intelligence (AI) in the form of deep learning bears promise for drug discovery and chemical biology, $\textit{e.g.}$, to predict protein structure and molecular bioactivity, plan organic synthesis, and design molecules $\textit{de novo}$. While most of the deep learning efforts in drug discovery have focused on ligand-based approaches, structure-based drug discovery has the potential to tackle unsolved challenges, such as affinity prediction for unexplored protein targets, binding-mechanism elucidation, and the rationalization of related chemical kinetic properties. Advances in deep learning methodologies and the availability of accurate predictions for protein tertiary structure advocate for a $\textit{renaissance}$ in structure-based approaches for drug discovery guided by AI. This review summarizes the most prominent algorithmic concepts in structure-based deep learning for drug discovery, and forecasts opportunities, applications, and challenges ahead.

We present temporally layered architecture (TLA), a biologically inspired system for temporally adaptive distributed control. TLA layers a fast and a slow controller together to achieve temporal abstraction that allows each layer to focus on a different time-scale. Our design is biologically inspired and draws on the architecture of the human brain which executes actions at different timescales depending on the environment's demands. Such distributed control design is widespread across biological systems because it increases survivability and accuracy in certain and uncertain environments. We demonstrate that TLA can provide many advantages over existing approaches, including persistent exploration, adaptive control, explainable temporal behavior, compute efficiency and distributed control. We present two different algorithms for training TLA: (a) Closed-loop control, where the fast controller is trained over a pre-trained slow controller, allowing better exploration for the fast controller and closed-loop control where the fast controller decides whether to "act-or-not" at each timestep; and (b) Partially open loop control, where the slow controller is trained over a pre-trained fast controller, allowing for open loop-control where the slow controller picks a temporally extended action or defers the next n-actions to the fast controller. We evaluated our method on a suite of continuous control tasks and demonstrate the advantages of TLA over several strong baselines.

Large Language Models (LLMs) have been the subject of active research, significantly advancing the field of Natural Language Processing (NLP). From BERT to BLOOM, LLMs have surpassed state-of-the-art results in various natural language tasks such as question answering, summarization, and text generation. Many ongoing efforts focus on understanding LLMs' capabilities, including their knowledge of the world, syntax, and semantics. However, extending the textual prowess of LLMs to symbolic reasoning has been slow and predominantly focused on tackling problems related to the mathematical field. In this paper, we explore the use of LLMs for automated planning - a branch of AI concerned with the realization of action sequences (plans) to achieve a goal, typically executed by intelligent agents, autonomous robots, and unmanned vehicles. We introduce Plansformer; an LLM fine-tuned on planning problems and capable of generating plans with favorable behavior in terms of correctness and length with reduced knowledge-engineering efforts. We also demonstrate the adaptability of Plansformer in solving different planning domains with varying complexities, owing to the transfer learning abilities of LLMs. For one configuration of Plansformer, we achieve ~97% valid plans, out of which ~95% are optimal for Towers of Hanoi - a puzzle-solving domain.

This paper describes Waymo's Collision Avoidance Testing (CAT) methodology: a scenario-based testing method that evaluates the safety of the Waymo Driver Automated Driving Systems' (ADS) intended functionality in conflict situations initiated by other road users that require urgent evasive maneuvers. Because SAE Level 4 ADS are responsible for the dynamic driving task (DDT), when engaged, without immediate human intervention, evaluating a Level 4 ADS using scenario-based testing is difficult due to the potentially infinite number of operational scenarios in which hazardous situations may unfold. To that end, in this paper we first describe the safety test objectives for the CAT methodology, including the collision and serious injury metrics and the reference behavior model representing a non-impaired eyes on conflict human driver used to form an acceptance criterion. Afterward, we introduce the process for identifying potentially hazardous situations from a combination of human data, ADS testing data, and expert knowledge about the product design and associated Operational Design Domain (ODD). The test allocation and execution strategy is presented next, which exclusively utilize simulations constructed from sensor data collected on a test track, real-world driving, or from simulated sensor data. The paper concludes with the presentation of results from applying CAT to the fully autonomous ride-hailing service that Waymo operates in San Francisco, California and Phoenix, Arizona. The iterative nature of scenario identification, combined with over ten years of experience of on-road testing, results in a scenario database that converges to a representative set of responder role scenarios for a given ODD. Using Waymo's virtual test platform, which is calibrated to data collected as part of many years of ADS development, the CAT methodology provides a robust and scalable safety evaluation.

When data is streaming from multiple sources, conventional training methods update model weights often assuming the same level of reliability for each source; that is: a model does not consider data quality of each source during training. In many applications, sources can have varied levels of noise or corruption that has negative effects on the learning of a robust deep learning model. A key issue is that the quality of data or labels for individual sources is often not available during training and could vary over time. Our solution to this problem is to consider the mistakes made while training on data originating from sources and utilise this to create a perceived data quality for each source. This paper demonstrates a straight-forward and novel technique that can be applied to any gradient descent optimiser: Update model weights as a function of the perceived reliability of data sources within a wider data set. The algorithm controls the plasticity of a given model to weight updates based on the history of losses from individual data sources. We show that applying this technique can significantly improve model performance when trained on a mixture of reliable and unreliable data sources, and maintain performance when models are trained on data sources that are all considered reliable. All code to reproduce this work's experiments and implement the algorithm in the reader's own models is made available.

We consider the problem of predictive monitoring (PM), i.e., predicting at runtime the satisfaction of a desired property from the current system's state. Due to its relevance for runtime safety assurance and online control, PM methods need to be efficient to enable timely interventions against predicted violations, while providing correctness guarantees. We introduce \textit{quantitative predictive monitoring (QPM)}, the first PM method to support stochastic processes and rich specifications given in Signal Temporal Logic (STL). Unlike most of the existing PM techniques that predict whether or not some property $\phi$ is satisfied, QPM provides a quantitative measure of satisfaction by predicting the quantitative (aka robust) STL semantics of $\phi$. QPM derives prediction intervals that are highly efficient to compute and with probabilistic guarantees, in that the intervals cover with arbitrary probability the STL robustness values relative to the stochastic evolution of the system. To do so, we take a machine-learning approach and leverage recent advances in conformal inference for quantile regression, thereby avoiding expensive Monte-Carlo simulations at runtime to estimate the intervals. We also show how our monitors can be combined in a compositional manner to handle composite formulas, without retraining the predictors nor sacrificing the guarantees. We demonstrate the effectiveness and scalability of QPM over a benchmark of four discrete-time stochastic processes with varying degrees of complexity.

5G及以后的移动网络将以前所未有的规模支持异质用例，从而要求自动控制和优化针对单个用户需求的网络功能。当前的蜂窝体系结构不可能对无线电访问网络（RAN）进行这种细粒度控制。为了填补这一空白，开放式运行范式及其规范引入了一个带有抽象的开放体系结构，该架构可以启用闭环控制并提供数据驱动和智能优化RAN在用户级别上。这是通过在网络边缘部署在近实时RAN智能控制器（接近RT RIC）上的自定义RAN控制应用程序（即XAPP）获得的。尽管有这些前提，但截至今天，研究界缺乏用于构建数据驱动XAPP的沙箱，并创建大型数据集以有效的AI培训。在本文中，我们通过引入NS-O-RAN来解决此问题，NS-O-RAN是一个软件框架，该框架将现实世界中的生产级近距离RIC与NS-3上的基于3GPP的模拟环境集成在一起，从而实现了XAPPS和XAPPS的开发自动化的大规模数据收集和深入强化学习驱动的控制策略的测试，以在用户级别的优化中进行优化。此外，我们提出了第一个特定于用户的O-RAN交通转向（TS）智能移交框架。它使用随机的合奏混合物，结合了最先进的卷积神经网络体系结构，以最佳地为网络中的每个用户分配服务基站。我们的TS XAPP接受了NS-O-RAN收集的超过4000万个数据点的培训，该数据点在近距离RIC上运行，并控制其基站。我们在大规模部署中评估了性能，这表明基于XAPP的交换可以使吞吐量和频谱效率平均比传统的移交启发式方法提高50％，而动机性开销较少。

我们定义了一个新颖的神经符号框架，论证奖励学习，该奖励学习将基于偏好的论点与现有方法结合了从人类反馈中加强学习的方法。我们的方法通过概括人类的偏好，减轻用户的负担并增加奖励模型的鲁棒性来改善先前的工作。我们通过许多实验证明了这一点。

社交机器人是一种自主机器人，通过参与其协作角色附带的社会情感行为，技能，能力和规则，与人们互动。为了实现这些目标，我们认为建模与用户的互动并将机器人行为调整为用户本人对其社会角色至关重要。本文提出了我们首次尝试将用户建模功能集成到社交和情感机器人中。我们提出了一种基于云的体系结构，用于建模用户机器人交互，以便使用不同类型的社交机器人重复使用该方法。